Events 2016

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    2 Novembre 2016, Journée de formation continue de la SWISS SCC, Lausanne

2 Novembre 2016, Journée de formation continue de la SWISS SCC, Lausanne

VITROSCREEN: IN VITRO SCIENCE AND NOT ONLY IN VITRO TEST
VitroScreen participated to the Swiss SCC event as sponsor because strongly believes that cosmetic claims can be substantiated, better understood and presented by using alternatives to conventional 2D cell culture and humans.
3D human skin models represent the new millenium reference in life sciences and their wide use will change the way to model, refine and support cosmetics efficacy and safety assessment by:

being complementary to in vivo evaluation;

adding value to direct and indirect consumer communication with deeper, stronger and more robust evidence of product efficacy corroborated by histological images;

being a unique and essential tool and not just an alternative, providing the mechanism of action and strong scientific evidences that cannot be obtained with in vivo approaches, either for practical or ethical reasons;

developing tools for formulators providing proof of concept for actives or prototype formulations, supporting technical scientific dossiers compliant to Regulation EC n. 1223/2009;

performing screening and comparing products with reproducible results during the development;

Quality Assurance principles are applied by VitroScreen throughout each study and research project, guaranteeing secured information management and providing the customer with in-depth reporting documents

VitroScreen does not simply deliver a test, but a completely new and different approach leading to a strong body of evidences. Being a flexible, reactive and pro-active partner open to innovation challenges, VitroScreen supports the customer’s management teams in formulation, Research & Development, marketing and communication, offering a unique expertise in the use of 3D human reconstructed tissue models for safety and efficacy testing within the cosmetic and pharmaceutical industries. A robust body of evidences and not only the result of single test for safety assessment is generated by performing the Multiple Endpoint Approach (MEA), leading to the [...]

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    September 2016, XXII Curso Internacional: Córnea y Cirugía Refractiva

September 2016, XXII Curso Internacional: Córnea y Cirugía Refractiva

Cancun, 14th-17th September 2016 – XXII Curso Internacional: Córnea y Cirugía Refractiva
On September 17th, 2016 Marisa Meloni, CEO of VitroScreen was invited to give a lecture on Preservatives and Eyedrops: How to evaluate and predict their effects at the “XXII Curso Internacional: Córnea y Cirugía Refractiva” organized by the Mexican Association of Oftalmology.
Dr Meloni gave a preliminary overview on the clinical and infraclinical effects of preservatives on the ocular surface. The key points highlighted in her lecture, based on historical and published data and testing protocols established in VitroScreen R&D Department, can be summarized as follows:

All preservatives activate an inflammatory process in 3D Human Corneal Epithelium after 24 hours (acute exposure);
All preservatives reduce the cellular visibility after 72 hours (repeated application);
All preservatives (including the so called “soft” or “vanishing” preservatives) lead to histological disruptions of the corneal epithelian barrier;
Repeated application better discriminates potential long term irritant from non irritant (ABAK);
Occludin gene expression is an early biomarker that correlates to superficial damage compared to the MTT cytotoxicity.

The MEA approach carried out at VitroScreen confirms that by adopting a sensitive and relevant in vitro experimental model with different exposures it is possible to underline toxicity mechanisms thus allowing to distinguish classes of preservatives and to better assess products irritation potential.

May 2016, VitroScreen Symposium

Milan, 19th May 2016 – Symposium on MUCOSAL IMMUNITY and IN VITRO SCIENCE
On May 19th VitroScreen organized an international Symposium on “Mucosal immunity and in vitro science” in Milan at the historic Palazzo Clerici with its world famous Tiepolo’s Gallery to celebrate its 15th anniversary.
The Symposium aimed at further developing the knowledge on how the human mucosal immune system plays a key role for the health and well-being of humans and analyzed the role played by in vitro science in understanding these mechanism in preclinical research.
Intruducing the Symposium, VitroScreen’s CEO Marisa Meloni, highlighted the Company’s vision not only to replace in vivo tests on animals and clinical trial on humans with in vitro experimental models, but also to foster an evolutionary approach to pre-clinical and toxicological evaluations. This approach, based on more predictable and reproducible technologies delivers value to different industrial sectors, encompassing pharma, cosmetics, nutitional and chemical. Professor Anna Maria Castellazzi (Centro Interuniversitario di Immunità e Nutrizione, Pavia University) analyzed the importance of the microbiota in close contact with the intestinal mucosa as a defense system against potentially immugenic or pathogenic factors which are present in the lumen.
The theme of mucosal immunity was deeply explored by the speakers focusing on the impact of microbiota and immuno mediated responses on different body barriers.
Carolina Devastato (Angelini SpA) dealt with the highly complex vaginal ecosystem and shared the results of a research jointly carried out with VitroScreen. The vaginal microflora has been reproduced on a vaginal epithelial model colonized with Lactobacillis and Candida Albicans. Christian Pellevoisin (Episkin Academy) underlined how human reconstructed skin and in vitro epidermal models allow the study of the interactions between the skin and the residential microbiota [...]

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    April 2016, Launch of Skinobs web platform for industrial cosmetic testing

April 2016, Launch of Skinobs web platform for industrial cosmetic testing

Skinobs is the 1st market and technology intelligence tool for industrial cosmetic testing (available from 2015), covering topics linking chemical analysis, toxicology, tolerance, in vitro and in vivo efficacy, use tests and sensory tests.

In 2 clicks and for free, Skinobs allows cosmeticians worldwide to identify the in vivo efficacy methods and the testing laboratories suitable for any product claim and optimizes the development of products in terms of performance, cost, speed, and innovation.

With more than 22,000 visits since its launch and peaks of 500 daily visits, Skinobs News is the reference web platform for innovative cosmetic testing.

Skinobs – Press release, April 2016

www.skinobs.com