April 2017, Society for Investigative Dermatology

Portland, Oregon, 26 – 29 April 2017 – SID

VitroScreen has recently presented three posters at the 76th Annual Meeting of the Society for Investigative Dermatology:


This last has been accepted as e-poster presentation.

January 2017, Journées Européennes de Dermocosmétologie

Lyon, 30 et 31 January 2017 – Journées Européennes de Dermocosmétologie
The Journées Européennes de Democosmétologie have the aim to promote high-level teaching and support interdisciplinary research projects in the field of cosmetology. In 2017, the Journées will be focused on ‘Personalized genomics and epigenetics, the future of dermocosmetology’.
Marisa Meloni, VitroScreen’s CEO, will give a lecture on Epigenetic associated to environmental stresses and skin aging
A novel UVA-induced inflammaging model will be presented. The model quantifies microRNAs targeting the NF-kB pathway whose altered gene expression may contribute to the modification of the inflammatory/anti-inflammatory balance, promoting oxidative stress, cellular senescence and age-related diseases.

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    2 Novembre 2016, Journée de formation continue de la SWISS SCC, Lausanne

2 Novembre 2016, Journée de formation continue de la SWISS SCC, Lausanne

VitroScreen participated to the Swiss SCC event as sponsor because strongly believes that cosmetic claims can be substantiated, better understood and presented by using alternatives to conventional 2D cell culture and humans.
3D human skin models represent the new millenium reference in life sciences and their wide use will change the way to model, refine and support cosmetics efficacy and safety assessment by:

being complementary to in vivo evaluation;

adding value to direct and indirect consumer communication with deeper, stronger and more robust evidence of product efficacy corroborated by histological images;

being a unique and essential tool and not just an alternative, providing the mechanism of action and strong scientific evidences that cannot be obtained with in vivo approaches, either for practical or ethical reasons;

developing tools for formulators providing proof of concept for actives or prototype formulations, supporting technical scientific dossiers compliant to Regulation EC n. 1223/2009;

performing screening and comparing products with reproducible results during the development;

Quality Assurance principles are applied by VitroScreen throughout each study and research project, guaranteeing secured information management and providing the customer with in-depth reporting documents

VitroScreen does not simply deliver a test, but a completely new and different approach leading to a strong body of evidences. Being a flexible, reactive and pro-active partner open to innovation challenges, VitroScreen supports the customer’s management teams in formulation, Research & Development, marketing and communication, offering a unique expertise in the use of 3D human reconstructed tissue models for safety and efficacy testing within the cosmetic and pharmaceutical industries. A robust body of evidences and not only the result of single test for safety assessment is generated by performing the Multiple Endpoint Approach (MEA), leading to the [...]

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    September 2016, XXII Curso Internacional: Córnea y Cirugía Refractiva

September 2016, XXII Curso Internacional: Córnea y Cirugía Refractiva

Cancun, 14th-17th September 2016 – XXII Curso Internacional: Córnea y Cirugía Refractiva
On September 17th, 2016 Marisa Meloni, CEO of VitroScreen was invited to give a lecture on Preservatives and Eyedrops: How to evaluate and predict their effects at the “XXII Curso Internacional: Córnea y Cirugía Refractiva” organized by the Mexican Association of Oftalmology.
Dr Meloni gave a preliminary overview on the clinical and infraclinical effects of preservatives on the ocular surface. The key points highlighted in her lecture, based on historical and published data and testing protocols established in VitroScreen R&D Department, can be summarized as follows:

All preservatives activate an inflammatory process in 3D Human Corneal Epithelium after 24 hours (acute exposure);
All preservatives reduce the cellular visibility after 72 hours (repeated application);
All preservatives (including the so called “soft” or “vanishing” preservatives) lead to histological disruptions of the corneal epithelian barrier;
Repeated application better discriminates potential long term irritant from non irritant (ABAK);
Occludin gene expression is an early biomarker that correlates to superficial damage compared to the MTT cytotoxicity.

The MEA approach carried out at VitroScreen confirms that by adopting a sensitive and relevant in vitro experimental model with different exposures it is possible to underline toxicity mechanisms thus allowing to distinguish classes of preservatives and to better assess products irritation potential.

May 2016, VitroScreen Symposium

Milan, 19th May 2016 – Symposium on MUCOSAL IMMUNITY and IN VITRO SCIENCE
On May 19th VitroScreen organized an international Symposium on “Mucosal immunity and in vitro science” in Milan at the historic Palazzo Clerici with its world famous Tiepolo’s Gallery to celebrate its 15th anniversary.
The Symposium aimed at further developing the knowledge on how the human mucosal immune system plays a key role for the health and well-being of humans and analyzed the role played by in vitro science in understanding these mechanism in preclinical research.
Intruducing the Symposium, VitroScreen’s CEO Marisa Meloni, highlighted the Company’s vision not only to replace in vivo tests on animals and clinical trial on humans with in vitro experimental models, but also to foster an evolutionary approach to pre-clinical and toxicological evaluations. This approach, based on more predictable and reproducible technologies delivers value to different industrial sectors, encompassing pharma, cosmetics, nutitional and chemical. Professor Anna Maria Castellazzi (Centro Interuniversitario di Immunità e Nutrizione, Pavia University) analyzed the importance of the microbiota in close contact with the intestinal mucosa as a defense system against potentially immugenic or pathogenic factors which are present in the lumen.
The theme of mucosal immunity was deeply explored by the speakers focusing on the impact of microbiota and immuno mediated responses on different body barriers.
Carolina Devastato (Angelini SpA) dealt with the highly complex vaginal ecosystem and shared the results of a research jointly carried out with VitroScreen. The vaginal microflora has been reproduced on a vaginal epithelial model colonized with Lactobacillis and Candida Albicans. Christian Pellevoisin (Episkin Academy) underlined how human reconstructed skin and in vitro epidermal models allow the study of the interactions between the skin and the residential microbiota [...]

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    April 2016, Launch of Skinobs web platform for industrial cosmetic testing

April 2016, Launch of Skinobs web platform for industrial cosmetic testing

Skinobs is the 1st market and technology intelligence tool for industrial cosmetic testing (available from 2015), covering topics linking chemical analysis, toxicology, tolerance, in vitro and in vivo efficacy, use tests and sensory tests.

In 2 clicks and for free, Skinobs allows cosmeticians worldwide to identify the in vivo efficacy methods and the testing laboratories suitable for any product claim and optimizes the development of products in terms of performance, cost, speed, and innovation.

With more than 22,000 visits since its launch and peaks of 500 daily visits, Skinobs News is the reference web platform for innovative cosmetic testing.

Skinobs – Press release, April 2016

8-9/12/2015, Journèes Jean-Paul Marty

Paris, 8-9 December 2015 – Journèes Jean-Paul Marty: Skin and Micro-organisms

The Journées Jean-Paul Marty are organized by the French Society of Cosmetology (SFC). This year the meeting addressed the scientific advance and innovation introduced on the theme of Skin & Micro-organisms.

Dr Marisa Meloni, VitroScreen CEO, contributed with a lecture on S. Aureus biofilm on in vitro reconstructed human epidermis to highlight the relevance of the biofilm model recently developed by VitroScreen and its relevant application in cosmetic and pharmaceutical sciences.

VitroScreen also presented a poster entitled: Modeling Atopic Dermatitis in Reconstituted Human Epidermis.

French Research Tax Credit (CIR) agreement

Paris, Septembre 2015

VitroScreen est agréé au titre du Crédit Impôt Recherche et du Crédit Impôt Innovation Français

En Septembre 2015 la Ministre de l’Education nationale de l’Enseignement supérieur et de la Recherche a accordé à VitroScreen l’agrément au titre du Crédit Impôt Recherche et du Crédit Impôt Innovation pour les années 2015, 2016 et 2017.

Cet agrément du crédit Impôt Recherche potentialise les partenariats déjà existants avec les sociétés de l’industrie cosmétique, dermo-cosmétique, pharmacie et agroalimentaire françaises. Il offre la possibilité à toutes les entreprises d’externaliser des projets de R&D et atteindre des objectifs plus ambitieux.

Cet agrément est la preuve que VitroScreen à travers sa platforme d’évaluation in vitro contribue au succès de recherche de ses partenaires et à l’innovation produit de ses clients.

19-05-2015 CellTox/IZSLER seminar on hepatotoxicity

Brescia, 19 May 2015 – CellTox/IZSLER seminar on hepatotoxicity

VitroScreen partecipated to the Seminar entitled ‘MOdels ON liver’, organized by the Italian Scientific Society CellTOX in collaboration with the ‘Instituto Zooprofilattico Sperimentale dalla Lombardia e dell’Emilia Romagna (IZSLER)’. The workshop report is presented in Altex 32(3), 2015.

Barbara De Servi, VitroScreen’s senior researcher, gave a presentation entitled: “3D co-coltures: characterization and applications of the microliver model”. The biological relevance of the 3D microliver model was described and its usefulness  in pre-clinical studies and drug discovery was presented. The toxicity of food ingredients, their mechanism of action and antioxidant activity as well as the hepatotoxicity of chemicals, pesticides and newly developed materials can also be assessed using the microliver model.

27/29-05-2015 GIQAR

Naples, 27/29 May 2015 – XXIV National Congress GIQAR

VitroScreen has partecipated to the Workshop entitled ‘La qualità e le GXP: l’asticella si sposta sempre più in alto’.

Euridice Santirocco, VitroScreen’s QA, presented a poster entitled: “Evaluation of the biocompatibility of medical devices for topical use: cytotoxicity and irritation potential”.