VitroScreen has contributed with the chapter «Tear Substitutes Development: In Vitro Immuno-competent Models» to this review article that summarizes the results of a consensus meeting held by a group of experts (within ESASO, www.esaso.org ) on the dry eye disease (DED) focusing on the importance and role of tear substitutes in the treatment of ocular surface.
Experts from Academia have focused on the new requirements of lacrimalsubstitutes, the importance of conducting rigorous clinical trials, the requirements of the upcoming European legislation on medical devices, the advances in the formulation of safer preservatives and the peculiarities of treatment in younger subjects: this last topic has a particular relevance becauseDED is starting to affect children and teenagers, possibly due to a prolonged use of digital devices which has been recently increased with e-learing, smart working and all related restrictions imposed by Covid-19 pandemic.
VitroScreen within the In Vitro Innovation Center activities is currentlyinvestigating on 3D human corneal epithelium model the side effects and damages induced by Bluelight (390-490nm) and oxidative stress on corneal surface.