The article describes the development and characterization of ORA®-DERMIS spheroids and, in particular, it shows the different features of spheroids derived from fibroblasts from donors of different ages (40 and 50 year-old donors).
The results suggest that ORA®-DERMIS spheroids are able to:
- preserve and maintain the phenotypic features of the original tissue
- recapitulate the main steps of tissue differentiation thanks to a more physiological 3D microenvironment which supports the physiological tissue evolution
- provide insights on the ability of primary fibroblasts to secrete and organize the dermal ECM with a continuous enrichment process
ORA®-Dermis model is a Microphysiological System (MPS) with an interesting potential use in personalized care and dermatological research on ageing processes and disease pathogenesis.
Link to the publication: www.dovepress.com/getfile.php?fileID=71905